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Good news for Sanofi-Aventis. The pharmaceutical giant has obtained a favorable opinion of the Commission on Transparency Multaq medical interest, reveals the Tribune Wednesday. This drug for cardiac arrhythmias in place of amiodarone which generates significant side effects, had been criticized by the French authorities as a renowned American Institute cardialogie.

The Transparency Committee eventually concluded that "the Multaq does not improve the medical service rendered in relation to amiodarone (…) but represents a useful supplementary therapy. Experts believe that the "medical service rendered" is "important" when they had considered "moderate" in the first review in March.

This advisory opinion warrants a refund of 65% of Multaq, but it does not fix the selling price. This will be negotiated with the Ministry of Health.The daily La Tribune said that the opinion of the Commission should result in a price lower than the products already marketed. The laboratory should therefore support price negotiations with a strong argument: the reduction of hospitalizations and deaths due to medication.

900 million euros turnover in 2013 horzon

While numerous patents expire Group, Sanofi-Aventis place great hope in the Multaq: Analysts expect 900 million euros turnover in 2013, according to business daily.

The new drug is already marketed in several countries like Germany, the United States, the United Kingdom, Denmark, Norway, Ireland, Switzerland or Canada. A spokesman for the pharmaceutical group has confirmed a target marketing Multaq in France by the end of the year.

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Malta takes a very dim view of the opening of the French market paris online and does everything to slow the process. This is the poker from the first to pay the price. Indeed, the opening to competition of the French market of online poker is postponed for one month, until late June because of an obstruction of Malta under EU rules, said the Agency France Presse (AFP) the entourage of the Department of Budget and confirming information site Challenges.fr

"We can not publish the implementation decree (for poker online) before June 28 It postponed a month because we are forced Malta, "says one with services Françoise Baroin.

A French law "relating to the introduction of competition and industry regulation of gambling and online gambling" was promulgated on May 13, followed by a dozen decrees.This legislation relates to sports paris, the paris horse and poker.

The Regulatory Authority online games (Arjel) should issue next Tuesday fifteen licenses to operators of online games, especially in order to start the paris during the FIFA World Cup (June 11-July 11 ).

Problem European procedure

The government had sent there over a year to the European Commission's draft legislation on online gaming, then notified Brussels implementing decrees, said the Budget Ministry. "Member States (EU) had three months to make their comments and Malta has chosen to do May 27", ie the last moment. France is obliged to meet in Brussels and Malta before issuing his decree. Paris now has one month to respond.

Malta, already established on the market for online games, contests a provision of the French law requiring players to register with an approved operator. This is contrary to the EU principle of free movement of persons and property.

"There is no problem on the merits. It is simply a procedural problem in Europe, as it has been commented at Bercy, stating that the grant Arjel as planned on Tuesday for its amenities paris sports, horse and poker. For the latter, many traders will await publication of the decree in late June. Still, the situation is embarrassing for the operators. Bwin, Unibet and Unibet already offer online poker. And waiting for regulatory approval to regularize their situation.

History! No fewer than three giants of French capitalism take their bow this spring. The vintage 2010 general meetings, which are in full swing in recent days, promises to be dominated by the departure of Presidents of Sanofi-Aventis, Total and Saint-Gobain. Jean-Francois Dehecq, Thierry Desmarest and Jean-Louis Beffa, former CEO during the course of their groups, have already sold one after the other the reins of the general direction of their dolphin. By one month, they also give up the presidency, he had kept time to pass the baton smoothly.

For a year, one quarter of the CAC 40 have experienced at their head movements, visible these days as AG. This is often an opportunity for groups to reconstruct the position of CEO, dear to the French tradition. Christophe de Margerie, and Pierre-Andre de Chalendar thus inherit full power Discount Total and Saint-Gobain.France Telecom, meanwhile, saw a rapid transition after the scandal of suicide. St?phane Richard, who took over on March 1, Didier Lombard Branch knows that it will not last: it is proposed as an administrator at the meeting of June 9, to get the Grail as CEO in spring 2011 .

Ultimately, if we exclude the Cr?dit Agricole – true to his rule called "four eyes" – and who will succeed Jean-Marie Sander Rene Carron as head of the group, the Germano-Canadian Christopher Viehbacher (Sanofi-Aventis ) is the only general managers to remain under supervision despite the departure of its president. Serge Weinberg takes effect in the torch left by Jean-Francois Dehecq, the founder of the pharmaceutical company.A matter of nationality? Last year, the board of Societe Generale had waived, under political pressure, to entrust the presidency to Britain's Tony Wyand after the resignation of Daniel Bouton. Rather than having a candidate imposed by the Elysee, the bank was then promoted its managing director Frederic Oud?a the rank of CEO and Tony Wyand placed at his side as vice president.

Vice President referent

If he returns to court, the model of the French boss is omnipotent and more often mitigated by the presence of a guardian "Jiminy Cricket" by his side. At Veolia, already, after the departure of Henri Proglio, his successor Anthony fawn followed closely since last fall by his vice-president, Louis Schweitzer. Axa similar pattern. Henri de Castries, chairman of the board so far, has certainly been converted CEO last week.But at the same time, Norbert Dentressangle, the owner of eponymous transport group, has been appointed as vice-chair, "referring independent director.

Jacques de Chateauvieux, who had succeeded to the presidency of the Executive to Claude Bebear, Axa's founder, had found himself as the structure to the Executive and Supervisory Board was not justified.

As at Societe Generale, had to adjust the statutes to give substance to this vice presidency, that does not exist in French law. Thursday, shareholders of Vinci will last for Yves-Thibault de Silguy at the podium as President. The great servant of the State, which had been called to the rescue in 2006 following the hectic departure of Antoine Zacharias, sits down on the vice-presidency. Xavier Huillard, the group general manager of concessions, makes him the scepter of CEO.A development designed to end the tensions that prevailed in Vinci.

Not easy, indeed, to live day to day relationship between a "chairman" and "CEO" in a foreign country that tradition. "France and the United States are the only countries where these functions remain separate," recalls Loic Dessaint, in Proxinvest, a consulting firm in corporate governance. In light of these latest twists, it appears increasingly that the wave of the separation of powers, meeting in the mid-2000s, showed more concern for some employers to ensure a smooth transition with a real cultural revolution. We had already seen, in 2009, Carlos Ghosn CEO of Renault erected at the term of office of Louis Schweitzer. The method remains valid.Essilor, Xavier Fontanet was withdrawn and the presidency since January 1, transmitting the general direction Hubert Sagnieres. Even the intended movement of 1 July for the specialist Veritas Geophysical GSC.

Finally, it may be tempting to take the highway in reverse, it can be expensive. Jean-Francois Roverato, CEO of Eiffage, who had time left for the operational reins back then paid dearly for this year. Its board of directors granted a renewal of his mandate for one year …

The De Beers diamond bet on a shortage of diamonds in the long term. To prolong the life of its mines, therefore he wants to reduce its production. Such a decision could have an immediate impact on prices, with an increase of 5% according to some analysts, De Beers alone representing 40% of sales of rough diamonds throughout the world.

The world provides a stabilization of its production to 40 million carats in the next two years, against 48 million carats in 2008.The predicted shortage should be accelerated by new demand from Asian countries, including China, where these stones are very popular online cash advance.

In twenty years, no site has been discovered that can compete with the mines operated by De Beers in South Africa or that of Alrosa in Russia.

After a difficult 2009 which resulted in losses, the diamond table on profits this year, and until 2014. Some analysts see the move as a preamble to a re-IPO of the group.

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The green color should still be the day the Paris Bourse. Comforted by the end of the Japanese Nikkei up on Monday, the CAC 40 should continue its momentum on Friday. The key index in Paris had ended the week up almost 2%, surpassing the 4000 points to 4050 points.

Investors should be reassured by Parisian rescue plan with Greek details, as expected, were finally unveiled this weekend. The European system, operational since Sunday, includes up to 30 billion euros in loan agreements with joint assistance from the IMF. The new fact in any case already boosted the euro. In morning trading, the euro is worth 1.3675 dollars, up 0.12% against the greenback.

On the face of macroeconomic indicators, no news likely to react to the markets is expected.Important data such as current accounts or French industrial production in the euro area, will in the coming days.

However, the quarterly publications begin Monday in France and the U.S. cash till payday. Intel, Google, Bank of America, or General Electric are expected across the Atlantic this week. The France oversee Alcoa or Atos Origin.

Values follow

In an interview with the Journal du Dimanche, the chief executive of Publicis said this weekend that the advertising investment is not expected to regain its 2008 levels by 2012.The latter also expressed readiness to re-evaluate its offer for the advertising of France Televisions, if the advertising was finally upheld.

France Telecom is in difficulty in Egypt where a court on Saturday confirmed its decision to block the bid from France Telecom on the minority of ECMS, the first mobile operator in terms of number of subscribers.

According to sources close to the deal, EADS will unveil its position on a possible bid to tender for the supply of tanker aircraft to the U.S. Air Force.

Alcoa publishes figures for its first quarter after market close in New York.

The Paris Bourse takes a deep breath. After recording, the day before, a new annual record over 4050 points, the CAC lost 0.67% to 4026.97 points. Everywhere in Europe, investors took advantage of the strong performance of recent days to garner a share of their profits. London and Frankfurt lost 0.22% and 0.48%.

Wall Street, which also navigates the unknown peaks over 18 months, was also a break. The Dow dropped 0.24% in session and the Nasdaq is 0.20%.

The minutes of the Fed meeting on 16 March confirmed that the U.S. central bank remained committed to maintaining its policy rates "unusually low", "for a period of time."But at the same time the debate on the need to adopt a real strategy for ending the crisis is more urgent and animated.

Concerns persist about Greece

Indeed, the United States but also in Europe, signs of economic recovery are daily becoming more numerous and tangible. Yesterday, activity in the private sector in the euro area recorded in March, its strongest growth in two and a half years.

Other good news, orders to German industry, the mainstay of the economy in Germany, continue to recover. However, the foreign exchange market, the euro retreated further against the greenback falling dollar sitting in 1.335 penalized by persistent concerns about the ability of Greece to refinance its debt and the fear of contagion from the crisis to other countries in the euro zone as Portugal, Spain or Italy.In Paris, profit-taking focused on areas that have risen more in exchange for a year and particularly on banking stocks, as well as automotive and technology.

The news was confirmed by a spokesman for Total, following a central works council. The Dunkirk refinery has finally closed its doors Monday. As the oil group had promised the 370 employees keep their jobs by creating a depot, a training center, a technical center and reclassifications.

The logistics depot would employ 15 people, training centers and technical assistance in refining approximately 225. Employees will be offered 80 positions in other refineries, 30 positions in other structures of Total in France and 20 employees will be granted "for early career.

The proposed closure of the Dunkirk refinery is the source of the national strike in late February that poses the threat of a shortage of fuel.The refinery has 370 direct employees and 400 to 450 employees subcontractors.

Total promised to each employee in the establishment of Flanders' work at Total matching skills. Another promise: "no closure or sale" of French refineries will happen within five years.

Substitution project

Before the start of the meeting, Total has confirmed its participation in the construction of an LNG terminal by EDF in the port of Dunkirk. The agreement provides for "an equity Total capital 'of society, Dunkerque LNG, a subsidiary of EDF responsible for the construction of this terminal will terminal.Ce regasification capacity of between 10 and 13 billion cubic meters per year. The decision regarding its actual construction will be taken before the summer and could be put into service in 2014.It remains "conditioned on obtaining all regulatory approvals and the completion of commercial procedures and tenders for construction."

This project would mobilize up to 1,200 people during construction "and could generate" at least fifty direct jobs, which should add about 150 jobs indirectly "in the operating phase out the two groups. The Industry Minister Christian Estrosi had rightly warned that the Dunkirk refinery would reopen if there was "no real alternative project" to maintaining employment.

But this news should not necessarily good news for employees. The CGT and Sud believe that this project is too distant and "inadequate" to compensate for job losses.For 12 hours, the employees of Dunkirk appear before a seat of Total Defense.

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Air France-KLM fails to emerge from the fog in which she sailed past four quarters. The airline announced on Wednesday a further loss in the third quarter of fiscal shifted 2009-2010, the fifth in a row. Over this period (October to December), the group garnered a net loss of 295 million euros. This is less than the 508 million the previous year but well above the 216 million expected by analysts. The operating loss also disappointed expectations, to -245 to -194 million against expected by the market.

In the third quarter, revenue fell 16% to 5.19 billion euros. Observers had expected 5.34 billion euros."The business has shown during this quarter are some signs of recovery but in an economic environment that remains challenging," the group said in a statement.

Operating loss record throughout the year

For more, Air France KLM expects operating profit in the fourth quarter of fiscal offset "the same as that of last year" was 574 million euros. This "given the expected recovery later in unit revenues, lower capacity and an increase of about 300 million dollars from the oil bill.

This means that at this rate, the operating loss over the whole year could reach a record. Indeed, nine months, the group's operating loss amounted already to 788 million euros.Adding to the loss of 574 million harvested in the fourth quarter, the operating loss over the entire year could exceed 1.3 billion euros.

In a more distant future, Air France-KLM confirms targeting a return to balanced operations for its fiscal year 2010-11, excluding the impact of oil hedges prior to 2009. The company relies on cost reductions, "expected a slight increase in unit revenues, the implementation of medium-haul product and restructuring initiated in cargo activity.

The general environment is showing signs of improvement in the airline also confirmed the International Air Transport Association (IATA). The situation could hardly be worse than in 2009.

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After the sharp market downturn in Paris last weekend, with the Cac 40 lost nearly 7% in 48 hours, and the misdirection of Asian Awards on Monday, investors in Paris should be cautious again. The future of the CAC 40 index was down 1.27% at 3563 points.

On the macroeconomic front, there will be no major indicator of both sides of the Atlantic, if not the economic survey of the Bank of France on the growth of France in the first quarter 2010.

Values follow

The year 2010 will be tougher than 2009 for the Franco-Belgian bank Dexia is the acceleration of the implementation of its restructuring plan which has received the green light from Brussels, said Sunday the group managing director .

EDF and Areva announced late Friday it reached an agreement on the processing of uranium used in nuclear power plants of the electrician, an issue at the heart of a dispute between the two groups for several weeks. The CEO of EADS, Louis Welsh said in Munich last Saturday he expected a "clarification" on the financing of additional costs for the Airbus A400M military "before the end of next week" Payday advance .

GDF Suez could revise its bid for International Power Plc, particularly the terms of its offer in cash, reports the Independent on Sunday, citing sources close to the French group.

The Autorit? des march?s financiers (AMF) has asked for new commitments in Belvedere in the case of warrants, which in recent weeks between the group of spirits to the Association for the Defense of Minority Shareholders (ADAM).

Bongrain has reported revenues down 7.4% on a comparable basis in 2009, affected by unfavorable economic environment.

Eiffage managed to stabilize its sales in 2009 thanks to a rebound in activity in the fourth quarter.

Several publications of companies are expected on Monday: Altran Technologies, pre-market Unibail Rodamco, after-hours trading, Le Noble Age and Devoteam. Faurecia brings an extraordinary general meeting regarding the capital increase related to the repurchase of Emcon.

Good news for Safran. Its subsidiary, Turbomeca has been chosen by Beijing to power the Chinese version of the new civilian EC175 helicopter jointly developed with Eurocopter, said its CEO Lutz Bertling. So far, the new helicopter is equipped with American engines Pratt & Whintney, and double engine choices are few things on the helicopters.

According to Voices, the American engine could not get the green light by U.S. authorities for exportrer in China some of its technologies.

This agreement confirms the thrust of Saffron to China. Last month, the group associated with GE in CFM International, has been chosen to equip the C 919 Chinese, the future Chinese medium-haul aircraft, a rival of Airbus A320 and Boieng B737.